Biomineralization in modern avian calcified eggshells: similarity versus diversity.
Connect. Tissue Res.
Dec, 2018
Avian eggshells are composed of several layers made of organic compounds and a mineral phase (calcite), and the general structure is basically the same in all species. A comparison of the structure, crystallography, and chemical composition shows that despite an overall similarity, each species has its own structure, crystallinity, and composition. Eggshells are a perfect example of the crystallographic versus biological concept of the formation and growth mechanisms of calcareous biominerals: the spherulitic-columnar structure is described as "a typical case of competitive crystal growth", but it is also said that the eggshell matrix components regulate eggshell mineralization. Electron back scattered ...
Impaired mineral quality in dentin in X-linked hypophosphatemia.
Connect. Tissue Res.
Dec, 2018
X-linked hypophosphatemia (XLH) is a skeletal disorder arising from mutations in the PHEX gene, transmitted in most cases as an X-linked dominant trait. PHEX deficiency leads to renal phosphate wasting and hypophosphatemia, as well as impaired mineralization of bone and dentin, resulting in severe skeletal and dental complications. Dentin mineralization defects appear as characteristic, large interglobular spaces resulting from the lack of fusion of calculospherites in the circumpulpal region during the mineralization process. Here, we examined changes in the composition and structure of dentin using Raman spectroscopy on XLH human teeth, and using transmission electron microscopy on the dentin of ...
Medicolegal Sidebar: Unnecessary Medical Care and Physician Liability.
Clin. Orthop. Relat. Res.
Dec, 2018
Erratum to: Can a Conical Implant Successfully Address Complex Anatomy in Primary THA? Radiographs and Hip Scores at Early Followup.
Clin. Orthop. Relat. Res.
Dec, 2018
Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization.
Connect. Tissue Res.
Dec, 2018
Purpose/Aim of the study. Collagen type XV (ColXV) was identified, in our previews studies, as a novel component of bone extracellular matrix. The present study aims to investigate ColXV localization during mineralization of osteodifferentiated human mesenchymal stem cells (hMSCs).
The enamel protein ODAM promotes mineralization in a collagen matrix.
Connect. Tissue Res.
Dec, 2018
Purpose/aim of the study: Odontogenic ameloblast-associated protein (ODAM) is predominantly expressed during the maturation stage of enamel formation and interacts strongly with amelotin (AMTN). AMTN is involved in enamel mineralization, but the effect of ODAM on mineralization has not been investigated. This study determined whether ODAM was able to induce hydroxyapatite (HA) mineralization in modified simulated body fluid (SBF) and in a collagen matrix in vitro.
The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth.
Connect. Tissue Res.
Dec, 2018
The tooth is different from the spicules and other urchin skeletal elements in that only the tooth contains both "high" and "very high" magnesium calcite, [Ca(1-X) Mg(X) CO3], where X is the mole fraction of Mg. We speculate that our newly discovered proline-alanine rich proteins, also containing sequences of acidic amino acids, may be involved in the formation of high magnesium and very high magnesium calcite.
Value-based Healthcare: Applying Time-driven Activity-based Costing in Orthopaedics.
Clin. Orthop. Relat. Res.
Dec, 2018
Wear Particle-induced Priming of the NLRP3 Inflammasome Depends on Adherent Pathogen-associated Molecular Patterns and Their Cognate Toll-like Receptors: An In Vitro Study.
Clin. Orthop. Relat. Res.
Dec, 2018
This cell culture study showed that adherent PAMPs are required for priming of the NLRP3 inflammasome by wear particles and this process is dependent on their cognate TLRs and TIRAP/Mal. In contrast, activation of the NLRP3 inflammasome by titanium particles is not dependent on adherent PAMPs. Animal and implant retrieval studies are needed to determine whether wear particles have similar effects on the NLRP3 inflammasome in vivo.
Letter to the Editor: Nazi Medicine-Part 2: The Downfall of a Profession and Pernkopf's Anatomy Atlas.
Clin. Orthop. Relat. Res.
Dec, 2018
Letter to the Editor: Editorial: The Nazi Musculoskeletal Experiments-Why Publish an Article About Them in 2018?
Clin. Orthop. Relat. Res.
Dec, 2018
The ER Ca
Connect. Tissue Res.
Dec, 2018
Bone and dentin development requires temporal and spatial deposition of calcium phosphate mineral. A host of proteins works in concert to contribute to this tightly regulated process while malfunction in this scheme often leads to pathological defects. We have reported earlier that DMP1 stimulation of preosteoblasts leads to calcium release from internal Ca